metS [2019-08-15 11:53:57]

methionyl-tRNA synthetase

Locus: BSU_00380

Isoelectric point: 4.96

Molecular weight: 76.01 kDa

Protein length: 664 aa

Gene length: 1995 bp

Function: translation

Product: methionyl-tRNA synthetase

Essential: yes

E.C.: 6.1.1.10

Synonyms

Genomic Context

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Categories containing this gene/protein

• Information processing → Protein synthesis, modification and degradation → Translation → Aminoacyl-tRNA synthetases
• Groups of genes → Essential genes
• Groups of genes → Phosphoproteins → Phosphorylation on a Ser residue

Gene

Coordinates: 45,633 → 47,627

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• ATP + L-methionine + tRNA^Met --> AMP + diphosphate + L-methionyl-tRNA^Met (according to UniProt)

Protein family

• Class-I aminoacyl-tRNA synthetase family (according to UniProt)

Modification

• phosphorylated on Ser-652 PubMed

Structure

• 1WE0 (from Thermus thermophilus hb8 mutant, 40% identity, 57% similarity) PubMed

Localization

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operons

• Genes: metS-yabD
  Description: PubMed

  Regulatory mechanism

  • Spo0A: repression, PubMed, in Spo0A regulon

  Regulation

  • repressed under conditions that trigger sporulation (Spo0A) PubMed

  Additional information

  • term-seq has identified a potential novel regulatory RNA element including an intrinsic transcription terminator upstream of metS PubMed

• Genes: metS

  Regulatory mechanism

  • Spo0A: repression, PubMed, in Spo0A regulon

  Regulation

  • repressed under conditions that trigger sporulation (Spo0A) PubMed

  Additional information

  • term-seq has identified a potential novel regulatory RNA element including an intrinsic transcription terminator upstream of metS PubMed

References

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